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ForumsNutrition & SupplementationCollagen peptides for GLP-1 skin elasticity — any evidence?

Collagen peptides for GLP-1 skin elasticity — any evidence?

Dr.Martinez Fri, Jun 5, 2026 at 7:31 PM 3 replies 149 viewsPage 1 of 1
Dr.Martinez
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Jun 5, 2026 at 7:31 PM#1

My appetite is suppressed enough that hitting a protein target is now the hardest part of the day, and everything I read assumes I can simply eat more.

What I actually want to know is how people are hitting a protein target on a genuinely suppressed appetite, because volume is the binding constraint rather than willingness.

I have searched first, so if this is covered somewhere point me at it and I will read it.

4 24AttorneyGrant, DebRD_ATL, KristenIndy and 1 other
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TrialNerd_Beth
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Jun 5, 2026 at 7:36 PM#2

Answering the narrow version, because the broad one does not have a single answer. On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie. Isolate powders, Greek yoghurt and cottage cheese, egg whites, lean fish, and tinned tuna all deliver a lot of protein in a small physical volume. Front-load it: appetite is usually least suppressed in the first hours after waking and worst on the day or two after dosing, so get the majority in early in the day and early in the week.

That is the short version; the long version is somebody else's post.

3 23PharmHunterJen, TomTeleRx, DoseLogDan
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Dr.GastroMayo
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Jun 5, 2026 at 7:41 PM#3
TrialNerd_Beth said:
On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie.

True, and anyone with reduced kidney function needs that target set by a clinician rather than a forum. High protein is safe in normal kidneys and is not automatically safe in impaired ones.

Last edited: Jun 6, 2026 at 12:41 AM
2 22COA_Karl, MikeFit_NJ
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HealthEcon_DC
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Jun 5, 2026 at 7:46 PM#4
Dr.Martinez said:
My appetite is suppressed enough that hitting a protein target is now the hardest part of the day, and everything I read assumes I can simply eat…

Can confirm the pattern Dr.Martinez describes. The RDA is the wrong reference and it is worth understanding why. 0.8 g/kg is the intake at which nitrogen balance is not negative in healthy weight-stable adults — a floor for deficiency prevention, not an optimum, and derived in a population that is not in a deficit. In a substantial energy deficit, protein requirement rises because amino acids are being oxidised for energy and because muscle protein synthesis is blunted. The literature on preserving lean mass during weight loss lands around 1.4 to 2.0 g/kg of reference body weight, which is roughly two to two and a half times the RDA.

Last edited: Jun 5, 2026 at 9:46 PM
1 21TirzTom
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Dr.EM_Chicago
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Jun 5, 2026 at 8:13 PM#5

Clinical perspective, offered as context rather than as advice.

DEXA scan update relevant to protein intake:

Scanned at months 0, 6, and 12. Here are the body comp numbers:

BaselineMonth 6Month 12
Total mass269 lbs219 lbs216 lbs
Fat mass119 lbs69 lbs51 lbs
Lean mass157 lbs144 lbs153 lbs
Body fat %38%30%25%

Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.4g/kg protein. The protein intake discussion needs to include body comp data, not just scale weight.

Last edited: Jun 6, 2026 at 12:13 AM
50 20lisa_labSD, adam_van, Dr.SurgeonPGH and 47 others
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