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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPsychological & BehavioralHas anyone dealt with relationship changes after weight loss?

Has anyone dealt with relationship changes after weight loss?

Dr.GutHealth Thu, Mar 5, 2026 at 12:57 PM 4 replies 754 viewsPage 1 of 1
Dr.GutHealth
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Mar 5, 2026 at 12:57 PM#1

The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

What I am trying to establish is how people separated a drug effect from the ordinary consequences of a large deficit and disrupted sleep, because I cannot.

Tell me what I have not thought of.

17 12VanRx_Mike, steve_okc, dave_SLC and 14 others
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Dr.ReproEndo
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Jan 2024
Scottsdale, AZ
Mar 5, 2026 at 2:32 PM#2
Dr.GutHealth said:
The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

Recovering from an eating disorder and using mental health: this is a complex situation and I want to be transparent about it.

I have a history of binge eating disorder. My psychiatrist, therapist, and prescribing doctor all collaborate on my care. The GLP-1 agonist has actually been therapeutic — it removes the biological urgency of binge impulses without relying on restriction.

This is NOT appropriate for all ED patients. Anorexia, bulimia, and restrictive EDs require different approaches. But for BED specifically, the evidence and my personal experience are positive. Always involve your mental health team.

Last edited: Mar 5, 2026 at 3:32 PM
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LarryQC_SD
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San Diego, CA
Mar 5, 2026 at 4:07 PM#3
Dr.ReproEndo said:
Recovering from an eating disorder and using mental health: this is a complex situation and I want to be transparent about it.
Dr.ReproEndo said:
...mental health should only be used alongside therapy...

I'd say therapy should be AVAILABLE to all GLP-1 patients, but requiring it as a precondition for treatment would create an access barrier.

Not everyone can afford therapy. Not everyone needs it. Some people do just fine with medication + lifestyle changes. But for those with emotional eating, body image issues, or disordered eating history, therapy is extremely valuable.

My recommendation: make mental health screening part of the initial assessment, offer therapy as a recommended adjunct, but don't gatekeep medication access behind it.

15 10TinaHashiRN, robert_kc, dan_philly and 12 others
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steve_okc
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Jul 2024
Oklahoma City, OK
Mar 5, 2026 at 5:42 PM#4
Dr.GutHealth said:
The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

Mine went the same way, slower. The detail I would add is minor and it is already implied above.

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TinaHashiRN
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Raleigh, NC
Mar 6, 2026 at 2:56 AM#5

From the other side of the consultation, briefly.

When to call your doctor about mental health side effects — a reference I wish I'd had:

Call immediately:

  • Severe abdominal pain (could be pancreatitis)
  • Vision changes (thyroid concern)
  • Lump in neck (thyroid nodule)
  • Severe vomiting/can't keep fluids down for 24h+

Schedule an appointment:

  • Persistent nausea beyond 4 weeks
  • Significant hair loss
  • Mood changes or depression
  • Gallbladder symptoms (RUQ pain after eating)
13 8MikeNYC_runner and 10 others
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