🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsNutrition & SupplementationDigestive enzyme supplementation — does it help with GLP-1 GI symptoms? Page 2

Digestive enzyme supplementation — does it help with GLP-1 GI symptoms?

Dr.GutHealth Wed, May 6, 2026 at 7:23 PM 7 replies 544 viewsPage 2 of 2
TrialNerd_Beth
Senior Member
2,345
11,234
Jan 2024
Bethesda, MD
May 7, 2026 at 11:11 AM#6
anders_CPH said:
The RDA is the wrong reference and it is worth understanding why.

I will push back on the powder-first advice. It works and it also trains people out of eating food, and when the drug stops the habits are what remain. Getting protein from meals is slower and holds up better afterwards.

49 19RickReta_CO, PharmHunterJen, TomTeleRx and 46 others
Reply Quote Save Share Report
NicoleRaleigh
Member
356
1,567
Aug 2024
Raleigh, NC
May 7, 2026 at 5:27 PM#7

The figures, for anyone assembling their own picture. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Last edited: May 7, 2026 at 6:27 PM
48 18MikeFit_NJ, InsuranceTom, WendyG_ATL and 45 others
Reply Quote Save Share Report
NurseAsh_DET
Member
356
1,567
Sep 2024
Detroit, MI
May 7, 2026 at 11:43 PM#8
TrialNerd_Beth said:
I will push back on the powder-first advice.

There is a second half to this that has not been said yet. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

47 17BrianDallas92, labquiet_amy, emily_PDX and 44 others
Reply Quote Save Share Report

PeptideMeter — Independent Peptide Analytics

Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.

View Results
jason_paloalto
Member
212
890
Nov 2024
Palo Alto, CA
May 8, 2026 at 6:00 AM#9

Following on from Dr.PeteFamMed — and this may be the naive question:

Whether the RDA is the wrong reference entirely during rapid weight loss, and what the actual target should be?

46 16andrew_nyc, Dr.EndoEP, GraceAZ_72 and 43 others
Reply Quote Save Share Report
Dr.GutHealth
Senior Member
1,456
7,890
Mar 2024
Minnesota
May 9, 2026 at 12:08 PM#10

Reporting back.

Front-loading was the answer. Same total intake, same drug, but two thirds of the protein before midday and I am hitting the target most days now.

46 19MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 43 others
Reply Quote Save Share Report

Similar Threads

Protein requirements on GLP-1: systematic review of RDA vs optimal intake8 replies
Micronutrient deficiency risk on GLP-1 — B12, D, iron, zinc, folate10 replies
High-protein meal plans for GLP-1 users — 1500-2000 kcal options9 replies
Meal prep Sunday — weekly high-protein recipes thread9 replies
Creatine monohydrate + GLP-1 — safety and lean mass preservation data14 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register