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ForumsNutrition & SupplementationZinc and GLP-1 — anyone have experience?

Zinc and GLP-1 — anyone have experience?

kate.chem Sun, Dec 28, 2025 at 3:42 PM 10 replies 1,040 viewsPage 1 of 2
kate.chem
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Dec 28, 2025 at 3:42 PM#1

A reference post rather than a discussion. Corrections are the point; I would rather this be right than mine. It is about micronutrient cover, and it is deliberately narrow — everything I am not confident about is marked as such.

What is actually established

A sustained drop to 1,100 or 1,200 calories reliably under-delivers a predictable set: B12, vitamin D, iron, folate, zinc and magnesium. Two of those are worth testing rather than guessing because the tests are cheap and the symptoms overlap with everything else — ferritin and B12. The rest a decent multivitamin covers, and there is no benefit in megadosing any of them.

The condition it depends on

The caveat that iron should be tested before supplementing, not after. Supplementing iron into normal stores is unpleasant at best and harmful in haemochromatosis.

The practical version

Cheap and worth having: ferritin, B12, vitamin D. Everything else on the deficiency list is adequately covered by a standard multivitamin at ordinary doses.

What I am not sure about

The narrow version of the question is which deficiencies actually show up when intake drops this far, and which are worth testing rather than supplementing blind. Happy to be told the question itself is wrong.

— kate.chem · corrections welcome and will be edited into this post with credit
35 5steve_okc, dave_SLC, FDA_TrackerJim and 32 others
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TrialTracker_MD
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Dec 28, 2025 at 4:24 PM#2
kate.chem said:
A sustained drop to 1,100 or 1,200 calories reliably under-delivers a predictable set: B12, vitamin D, iron, folate, zinc and magnesium.

Iron studies on micronutrients — important especially for women:

MarkerBaselineMonth 6After Supplementation
Ferritin562451
Iron865694
TIBC316386346
Transferrin Sat28%16%25%

My ferritin cratered at month 6 from reduced dietary intake. Iron bisglycinate 36mg with vitamin C brought it back up. Don't wait for anemia symptoms — test proactively.

Last edited: Dec 28, 2025 at 9:24 PM
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julia.endo
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Dec 28, 2025 at 5:06 PM#3
kate.chem said:
A sustained drop to 1,100 or 1,200 calories reliably under-delivers a predictable set: B12, vitamin D, iron, folate, zinc and magnesium.

Vitamin and mineral labs to check while on micronutrients — my doctor orders these quarterly:

  • B12: Can drop due to reduced GI absorption. Mine went from 650 to 380 — now supplementing.
  • Iron/Ferritin: Reduced food intake = reduced iron. Ferritin dropped from 73 to 30. Supplementing.
  • Vitamin D: Was already low (20 ng/mL), now taking 5000 IU daily.
  • Folate: Stable, no issues.
  • Zinc: Slightly low, added a multivitamin with zinc.

Nutritional deficiencies are a real risk when you're eating significantly less. Don't skip your labs!

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LindaRN_retired
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Dec 28, 2025 at 5:48 PM#4
julia.endo said:
Vitamin and mineral labs to check while on micronutrients — my doctor orders these quarterly: B12: Can drop due to reduced GI absorption.

Vitamin D levels and micronutrients: an often-overlooked connection. Obese individuals store vitamin D in adipose tissue, making it less bioavailable. As you lose fat, vitamin D can actually increase WITHOUT supplementation.

My trajectory: Baseline 18 ng/mL → Month 6 (with supplement) 42 ng/mL → Month 12 48 ng/mL. Target is 40-60 ng/mL. Adequate vitamin D supports immune function, bone health, and mood — all relevant during weight loss.

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alex_tucson
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Dec 28, 2025 at 9:46 PM#5
TrialTracker_MD said:
Iron studies on micronutrients — important especially for women: Marker Baseline Month 6 After Supplementation Ferritin 56 24 51 Iron 86 56 94 TIBC…

Adding a me-too, because a thread of one person's experience is not much use. The detail I would add is minor and it is already implied above.

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