Dr.AddMedPHL said:

On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie.

I will push back on the powder-first advice. It works and it also trains people out of eating food, and when the drug stops the habits are what remain. Getting protein from meals is slower and holds up better afterwards.

I would rather be corrected than agreed with, if it comes to it.

One concrete data point for the thread. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

I would rather be corrected than agreed with, if it comes to it.

Dr.ObesityLA said:

I will push back on the powder-first advice.

Coming at Dr.ObesityLA’s question from a different direction. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.

Following on from mark_tokyo — and this may be the naive question:

Whether the RDA is the wrong reference entirely during rapid weight loss, and what the actual target should be?

Reporting back.

Front-loading was the answer. Same total intake, same drug, but two thirds of the protein before midday and I am hitting the target most days now.