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ForumsNutrition & SupplementationProtein requirements on GLP-1: systematic review of RDA vs optimal intake — my results so far Page 3

Protein requirements on GLP-1: systematic review of RDA vs optimal intake — my results so far

laura_annarbor Wed, Sep 10, 2025 at 8:08 AM 30 replies 1,520 viewsPage 3 of 6
bbq_ray_KC
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Sep 13, 2025 at 5:16 PM#11
TrialTracker_MD said:
On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie.

Thank you — that is the clearest version of this I have read, and I have read a lot of them.

35 8COA_Karl, MikeFit_NJ, InsuranceTom and 32 others
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NurseLeah_Nash
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Sep 13, 2025 at 7:56 PM#12

From the other side of the consultation, briefly.

DEXA scan update relevant to protein intake:

Scanned at months 0, 6, and 12. Here are the body comp numbers:

BaselineMonth 6Month 12
Total mass281 lbs216 lbs218 lbs
Fat mass121 lbs81 lbs53 lbs
Lean mass159 lbs152 lbs155 lbs
Body fat %42%32%22%

Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.6g/kg protein. The protein intake discussion needs to include body comp data, not just scale weight.

36 9BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 33 others
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BethLabQueen
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Sep 13, 2025 at 10:36 PM#13
andrew_nyc said:
The gap between trial results and real-world results is consistent and it is not fraud.

I read this differently from andrew_nyc, on substance rather than tone. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.

Last edited: Sep 13, 2025 at 11:36 PM
37 10lori_vegas, Dr.PulmRoch, maya_sedona and 34 others
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Dr.PathRoch
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Sep 14, 2025 at 1:16 AM#14

One concrete data point for the thread. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

Worth separating that from the trial evidence, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

38 11SaraMom3, Dr.MetabolicMD, RetaRick_CA and 35 others
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mike_mod
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Sep 14, 2025 at 3:56 AM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Report rather than reply if it drifts again.

39 12PurityPaulOR, MaxMetOK, MounjBrad and 36 others
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