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Evidence-based GLP-1 & peptide discussion since 2023
ForumsNutrition & SupplementationHas anyone dealt with high-protein meal plans for glp-1 users?

Has anyone dealt with high-protein meal plans for glp-1 users?

NicoleRaleigh Sun, Aug 24, 2025 at 3:34 PM 12 replies 1,229 viewsPage 1 of 3
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NicoleRaleigh
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Aug 24, 2025 at 3:34 PM#1

My appetite is suppressed enough that hitting a protein target is now the hardest part of the day, and everything I read assumes I can simply eat more.

What I actually want to know is whether the RDA is the wrong reference entirely during rapid weight loss, and what the actual target should be.

I would rather have one careful answer than five confident ones.

31 1InsuranceTom, WendyG_ATL, SaraMom3 and 28 others
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mike_nyc
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Aug 24, 2025 at 4:12 PM#2

Short answer first, then the reasoning. On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie. Isolate powders, Greek yoghurt and cottage cheese, egg whites, lean fish, and tinned tuna all deliver a lot of protein in a small physical volume. Front-load it: appetite is usually least suppressed in the first hours after waking and worst on the day or two after dosing, so get the majority in early in the day and early in the week.

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Dr.NateNeph
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Aug 24, 2025 at 4:50 PM#3
mike_nyc said:
On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie.

True, and anyone with reduced kidney function needs that target set by a clinician rather than a forum. High protein is safe in normal kidneys and is not automatically safe in impaired ones.

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Dr.EndoEP
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Aug 24, 2025 at 5:28 PM#4
NicoleRaleigh said:
My appetite is suppressed enough that hitting a protein target is now the hardest part of the day, and everything I read assumes I can simply eat…

Same position here, arrived at the long way round. The RDA is the wrong reference and it is worth understanding why. 0.8 g/kg is the intake at which nitrogen balance is not negative in healthy weight-stable adults — a floor for deficiency prevention, not an optimum, and derived in a population that is not in a deficit. In a substantial energy deficit, protein requirement rises because amino acids are being oxidised for energy and because muscle protein synthesis is blunted. The literature on preserving lean mass during weight loss lands around 1.4 to 2.0 g/kg of reference body weight, which is roughly two to two and a half times the RDA.

Last edited: Aug 24, 2025 at 7:28 PM
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PharmD_Rodriguez
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Aug 24, 2025 at 9:00 PM#5

From the other side of the consultation, briefly.

DEXA scan update relevant to protein intake:

Scanned at months 0, 6, and 12. Here are the body comp numbers:

BaselineMonth 6Month 12
Total mass246 lbs211 lbs213 lbs
Fat mass116 lbs66 lbs48 lbs
Lean mass154 lbs153 lbs150 lbs
Body fat %39%33%22%

Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.4g/kg protein. The protein intake discussion needs to include body comp data, not just scale weight.

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