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ForumsNutrition & SupplementationMagnesium supplementation on GLP-1 — need advice

Magnesium supplementation on GLP-1 — need advice

sophie_paris Fri, May 17, 2024 at 4:23 AM 13 replies 2,119 viewsPage 1 of 3
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sophie_paris
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Paris, FR
May 17, 2024 at 4:23 AM#1

Two litres a day, no added salt, and a persistent headache that I spent a month attributing to the medication.

The bit I cannot resolve on my own is why hydration goes wrong on this specifically, given that nobody is telling us to drink less.

Practical detail welcome, however dull — the duller the better.

12 7SallyK_inj, CryptoCarl, MariaRD and 9 others
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kate.chem
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May 17, 2024 at 4:28 AM#2
sophie_paris said:
Two litres a day, no added salt, and a persistent headache that I spent a month attributing to the medication.

Helpful anti-nausea foods for hydration users:

  • Ginger (tea, chews, supplements — all work)
  • Peppermint (tea or oil capsules)
  • Plain crackers or rice cakes
  • Bananas (easy to digest, replenish potassium)
  • Clear broth (hydration + sodium)
  • Small amounts of protein (chicken breast, plain Greek yogurt)

Avoid: greasy foods, spicy foods, large meals, lying down after eating. Keep meals small and frequent — I do 5-6 mini meals/day.

Last edited: May 17, 2024 at 7:28 AM
11 6VanRx_Mike, steve_okc, dave_SLC and 8 others
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denise_HTX
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Houston, TX
May 17, 2024 at 4:33 AM#3
kate.chem said:
Helpful anti-nausea foods for hydration users: Ginger (tea, chews, supplements — all work) Peppermint (tea or oil capsules) Plain crackers or rice…

Electrolyte monitoring on hydration — especially important during early titration when GI effects are most pronounced:

  • Sodium: 139 mEq/L (normal, but was low at week 2 from vomiting)
  • Potassium: 3.9 mEq/L (supplement if below 3.5)
  • Magnesium: 1.9 mg/dL (supplementing with glycinate)
  • Phosphorus: 3.3 mg/dL (normal)

Low electrolytes cause muscle cramps, heart palpitations, and fatigue — symptoms often blamed on the medication itself. Check your levels before assuming it's a drug side effect.

10 5JessicaH_TX, KevinCompounds, TirzTom and 7 others
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carlos_SATX
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Oct 2024
San Antonio, TX
May 17, 2024 at 4:38 AM#4
sophie_paris said:
Two litres a day, no added salt, and a persistent headache that I spent a month attributing to the medication.

Second this.

9 4LindaRN_retired, tommy_boulder, hyun_seoul and 6 others
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Dr.ReproEndo
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Scottsdale, AZ
May 17, 2024 at 5:04 AM#5

Clinical perspective, offered as context rather than as advice.

Muscle cramps on hydration — anyone else? I was getting severe leg cramps at night, especially calves. Bloodwork showed my magnesium was low.

GLP-1 agonists can cause electrolyte shifts due to reduced food intake and GI effects. Get your electrolytes checked and supplement accordingly. I take magnesium glycinate 400mg + potassium gluconate 99mg daily and cramps are gone.

8 3carl_compliance, DanielChem_CHI, marco_milano and 5 others
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