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ForumsNutrition & SupplementationZinc and GLP-1 — looking for input

Zinc and GLP-1 — looking for input

CryptoCarl Thu, Feb 8, 2024 at 6:24 AM 51 replies 3,021 viewsPage 1 of 11
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CryptoCarl
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Feb 8, 2024 at 6:24 AM#1

I started taking a multivitamin as insurance and then found out that two of the things I was actually short of were the two it barely contains.

What I actually want to know is which deficiencies actually show up when intake drops this far, and which are worth testing rather than supplementing blind.

Practical detail welcome, however dull — the duller the better.

12 7CryptoCarl, MariaRD, AussieAnna and 9 others
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PharmacoVig_BOS
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Feb 8, 2024 at 8:21 AM#2
CryptoCarl said:
I started taking a multivitamin as insurance and then found out that two of the things I was actually short of were the two it barely contains.

Vitamin and mineral labs to check while on micronutrients — my doctor orders these quarterly:

  • B12: Can drop due to reduced GI absorption. Mine went from 650 to 380 — now supplementing.
  • Iron/Ferritin: Reduced food intake = reduced iron. Ferritin dropped from 67 to 24. Supplementing.
  • Vitamin D: Was already low (18 ng/mL), now taking 5000 IU daily.
  • Folate: Stable, no issues.
  • Zinc: Slightly low, added a multivitamin with zinc.

Nutritional deficiencies are a real risk when you're eating significantly less. Don't skip your labs!

11 6Dr.GutHealth, amsterdam_pete, LondonLisa and 8 others
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KetoKyle
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Feb 8, 2024 at 10:18 AM#3
PharmacoVig_BOS said:
Vitamin and mineral labs to check while on micronutrients — my doctor orders these quarterly: B12: Can drop due to reduced GI absorption.

Blood count monitoring for micronutrients: my doctor noticed my MCV (mean corpuscular volume) trending up at month 6: 91 → 96 fL. This flagged potential B12 or folate deficiency.

Sure enough, B12 had dropped from 620 to 340 pg/mL. Started B12 injections monthly and MCV normalized within 2 months. GLP-1 agonists can impair B12 absorption — this is a real clinical concern that deserves routine monitoring.

Last edited: Feb 8, 2024 at 11:18 AM
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maria_elpaso
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Feb 8, 2024 at 12:15 PM#4
CryptoCarl said:
I started taking a multivitamin as insurance and then found out that two of the things I was actually short of were the two it barely contains.

Can confirm. Same sequence, different timescale.

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traveltech_sara
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Feb 8, 2024 at 11:46 PM#5

Adding the clinical framing, because it changes how the question reads.

Iron studies on micronutrients — important especially for women:

MarkerBaselineMonth 6After Supplementation
Ferritin672052
Iron975790
TIBC332402342
Transferrin Sat32%17%29%

My ferritin cratered at month 6 from reduced dietary intake. Iron bisglycinate 36mg with vitamin C brought it back up. Don't wait for anemia symptoms — test proactively.

8 3BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 5 others
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