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ForumsDosing & ProtocolsSemaglutide titration: 0.25→0.5→1.0→1.7→2.4mg optimal schedule Page 10

Semaglutide titration: 0.25→0.5→1.0→1.7→2.4mg optimal schedule

Dr.Martinez Mon, Feb 26, 2024 at 4:00 PM 332 replies 13,278 viewsPage 10 of 20
SallyK_inj
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Mar 13, 2024 at 11:45 AM#46
TomTeleRx said:
The version of this that has an answer is narrower than the version being asked.

That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.

22 22amy_econ_NJ, bbq_ray_KC, oliver_london and 19 others
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Dr.Martinez
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Mar 14, 2024 at 12:14 AM#47

OP back with an update, since a thread like this is useless without one.

Six weeks on from posting: I stopped reading the weekly number and started reading a four-week average, and the "stall" I opened this thread about was a 1.8kg loss I could not see.

21 21traveltech_sara, AttorneyGrant, DebRD_ATL and 18 others
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jim_asheville
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Mar 14, 2024 at 12:43 PM#48

Clinical perspective, offered as context rather than as advice. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

Ask again with the specifics and you will get a better answer than this one.

Last edited: Mar 14, 2024 at 3:43 PM
20 20NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 17 others
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mia_MS2
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Mar 15, 2024 at 1:11 AM#49
jim_asheville said:
If two explanations both fit, the useful question is which one predicts something the other does not.

Same pattern here, and in the same order. The detail I would add is minor and it is already implied above.

Last edited: Mar 15, 2024 at 4:11 AM
19 19steve_okc, dave_SLC, FDA_TrackerJim and 16 others
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CanadaChris
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Mar 15, 2024 at 1:39 PM#50
jim_asheville said:
If two explanations both fit, the useful question is which one predicts something the other does not.

There is a second half to this that has not been said yet. Holding longer is the underrated move. A step that is uncomfortable at week two is frequently comfortable at week six with no change in dose, because the gastric-emptying component tachyphylaxes while the appetite effect persists. Escalating at week two throws that adaptation away.

47 22lori_vegas, Dr.PulmRoch, maya_sedona and 44 others
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