PharmacoVig_BOS said:

Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

tony_orlando said:

Agreed on the arithmetic, with one condition: holding indefinitely at a dose that is not doing anything is not patience, it is a stall with a nice…

Thank you — that is the clearest version of this I have read, and I have read a lot of them. I will report back once I have actually tried it.

PharmacoVig_BOS said:

Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.

The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

Moderator note: the sourcing question belongs in the vendor section and has been split out. Report rather than reply if it drifts again.