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Evidence-based GLP-1 & peptide discussion since 2023
ForumsDosing & ProtocolsHas anyone dealt with dose escalation too fast? recognizing over-titration symptoms? Page 3

Has anyone dealt with dose escalation too fast? recognizing over-titration symptoms?

traveltech_sara Sat, Mar 28, 2026 at 7:33 PM 26 replies 774 viewsPage 3 of 6
JenPlateau
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Nov 2024
Missouri
Mar 29, 2026 at 3:41 PM#11
Dr.GastroMayo said:
A step that is uncomfortable at week two is frequently comfortable at week six with no change in dose, because the gastric-emptying component…

That reframing is the part I needed. I will report back once I have actually tried it.

Last edited: Mar 29, 2026 at 9:41 PM
26 24HPLC_Greg, LibrarianMeg, bri_stats and 23 others
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pat_auckland
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Jun 2024
Auckland, NZ
Mar 29, 2026 at 7:46 PM#12

From the other side of the consultation, briefly. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.

Last edited: Mar 29, 2026 at 11:46 PM
27 0wanda_boise, NurseAsh_DET, BenResearch_OR and 24 others
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julia.endo
Senior Member
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Feb 2024
Cincinnati, OH
Mar 29, 2026 at 11:51 PM#13
LibrarianMeg said:
Dose escalation anxiety for titration: I was terrified to move from 0.5mg to 1.0mg based on horror stories in this forum.

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

Last edited: Mar 30, 2026 at 5:51 AM
28 1hans_munich, jason_sac26, chris_chi24 and 25 others
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Dr.PathRoch
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Rochester, MN
Mar 30, 2026 at 3:55 AM#14

The figures, for anyone assembling their own picture. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

29 2SaraMom3, Dr.MetabolicMD, RetaRick_CA and 26 others
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mike_mod
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Mar 30, 2026 at 7:59 AM#15

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. Tagging this one for the weekly digest.

30 3PurityPaulOR, MaxMetOK, MounjBrad and 27 others
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