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ForumsPharmacology & MechanismsGLP-1R desensitization — β-arrestin-mediated internalization Page 4

GLP-1R desensitization — β-arrestin-mediated internalization

NeuroNate Mon, Jun 8, 2026 at 3:41 AM 18 replies 396 viewsPage 4 of 4
mia_MS2
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Jun 8, 2026 at 8:58 PM#16
Dr.PulmRoch said:
Start from the measurement rather than the conclusion.

Can confirm. Same sequence, different timescale. Posting only so the count is not one.

Last edited: Jun 8, 2026 at 11:58 PM
1 24ricardo_MIA
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Dr.MetabolicMD
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Jun 8, 2026 at 9:19 PM#17
josh_phd_bmore said:
Keep the original post as written when you update it, and add the correction underneath.

Pushing back on josh_phd_bmore here. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

2 0PedsEndoPhilly, SleepDoc_PDX
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raj_cambridge
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Jun 8, 2026 at 9:40 PM#18
josh_phd_bmore said:
Keep the original post as written when you update it, and add the correction underneath.

True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.

That is the short version; the long version is somebody else's post.

Last edited: Jun 8, 2026 at 10:40 PM
3 1TomTeleRx, DoseLogDan, SleepFixSam
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ZaraB_AL
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Jun 8, 2026 at 10:01 PM#19
josh_phd_bmore said:
Keep the original post as written when you update it, and add the correction underneath.

This is exactly what I could not find anywhere else. Adding it to my notes with a link back to this thread.

4 2TrialTracker_MD, JennaRN, LabKate and 1 other
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mike_mod
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Jun 8, 2026 at 10:22 PM#20

Moderator note: a couple of off-topic posts removed. Tagging this one for the weekly digest.

Last edited: Jun 9, 2026 at 12:22 AM
26 24PurityPaulOR, MaxMetOK, MounjBrad and 23 others
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