GenomicsKate said:

PeptideChemSF said: ...but the FDA says semaglutide...

Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were relying on physical fullness feel the effect fade while the appetite effect is still working.

That is the short version; the long version is somebody else's post.

Adding the numbers, since they settle part of this. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

A narrower follow-up, since the general answer is now clear:

Which effects tachyphylax and which persist, because the answer explains why tolerability improves while the appetite effect keeps working?

VendorMark said:

If you are going to change something, change one thing and give it long enough to express itself.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

Ask again with the specifics and you will get a better answer than this one.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Carry on.