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ForumsPharmacology & MechanismsStructure-function of tirzepatide — unimolecular dual agonist design Page 3

Structure-function of tirzepatide — unimolecular dual agonist design

PeptideChemSF Thu, May 21, 2026 at 12:31 AM 14 replies 437 viewsPage 3 of 3
mel_PDX
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May 26, 2026 at 12:38 PM#11
NurseLeah_Nash said:
Steady state is faster than people expect: half-life about five days, so you are at plateau in roughly three to four weeks rather than five.

Thank you for spelling out the reasoning rather than just the conclusion. I will report back once I have actually tried it.

30 5Dr.NateNeph, PharmD_Rodriguez, julia.endo and 27 others
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roxy_nash
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May 26, 2026 at 8:24 PM#12

From the other side of the consultation, briefly. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.

Last edited: May 27, 2026 at 2:24 AM
29 4roxy_nash, tony_orlando, Dr.NephBHM_UK and 26 others
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LarryQC_SD
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May 27, 2026 at 4:10 AM#13
Dr.ObesityMed said:
If two explanations both fit, the useful question is which one predicts something the other does not.

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

28 3TinaHashiRN, robert_kc, dan_philly and 25 others
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BethLabQueen
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May 27, 2026 at 11:56 AM#14

The figures, for anyone assembling their own picture. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

Last edited: May 27, 2026 at 12:56 PM
27 2cory_ATX, lori_vegas, Dr.PulmRoch and 24 others
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Admin
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May 27, 2026 at 7:42 PM#15

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Tagging this one for the weekly digest.

26 1PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 23 others
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