DebRD_ATL said:

Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

This matches mine closely enough to be worth saying so out loud. Posting only so the count is not one.

DebRD_ATL said:

Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

Adding the part of the answer the thread has not reached. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

Moderator note: the sourcing question belongs in the vendor section and has been split out. No action needed from anybody.

A narrower follow-up, since the general answer is now clear:

Did your prescriber agree with that reading, and if not what was their objection?

greg_boulder said:

If two explanations both fit, the useful question is which one predicts something the other does not.

This is where I part company with the consensus forming above. The counter-case has not been addressed. Somebody upthread described the situation that does not fit, and the thread moved on rather than engaging with it, which is the failure mode this board is supposed to avoid.

I would rather be corrected than agreed with, if it comes to it.