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ForumsPharmacology & MechanismsBiased agonism at GLP-1R — my results so far Page 3

Biased agonism at GLP-1R — my results so far

nancy_portland Mon, May 4, 2026 at 2:29 AM 12 replies 520 viewsPage 3 of 3
Dr.BariatricHTX
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May 7, 2026 at 3:03 AM#11
SarahChen_PharmD said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

No disagreement, though it depends on where somebody is starting from, and this thread has been assuming a starting point nobody stated.

30 5CarlaRPh_TPA, steph_laguna, fiona_glasgow and 27 others
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sarah_TO
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May 9, 2026 at 10:56 PM#12
PharmacoVig_BOS said:
The mechanism is more central than most summaries suggest.

Thank you for spelling out the reasoning rather than just the conclusion. Printing the relevant bit and taking it with me.

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PeptideSynthNJ
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May 12, 2026 at 6:51 PM#13
SarahChen_PharmD said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

I read this differently from SarahChen_PharmD, on substance rather than tone. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

28 3BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 25 others
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Dr.NateNeph
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May 15, 2026 at 2:47 PM#14

One concrete data point for the thread. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

Last edited: May 15, 2026 at 4:47 PM
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mike_mod
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May 18, 2026 at 10:45 AM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. No action needed from anybody.

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