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Evidence-based GLP-1 & peptide discussion since 2023
ForumsDosing & ProtocolsDose-response curves — what worked for you? Page 3

Dose-response curves — what worked for you?

Dr.PathRoch Tue, Jul 29, 2025 at 7:01 PM 13 replies 1,404 viewsPage 3 of 3
LibrarianMeg
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Jul 31, 2025 at 2:53 PM#11
Dr.AddMedPHL said:
The mechanism and the magnitude are separate questions.

No disagreement with Dr.AddMedPHL. One condition attached. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.

Happy to go further on any of that.

45 20Dr.NateNeph, PharmD_Rodriguez, julia.endo and 42 others
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bbq_ray_KC
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Jul 31, 2025 at 7:16 PM#12
SkepticalSean said:
That is right for the weekly injectables.

Bookmarking. The distinction being drawn above is the one nobody else makes. Adding it to my notes with a link back to this thread.

44 19MikeFit_NJ, InsuranceTom, WendyG_ATL and 41 others
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pete_nash
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Jul 31, 2025 at 11:39 PM#13
Dr.AddMedPHL said:
The mechanism and the magnitude are separate questions.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

Last edited: Aug 1, 2025 at 5:39 AM
43 18mike_mod, SarahChen_PharmD, sarah.morrison and 40 others
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anders_CPH
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Aug 1, 2025 at 4:02 AM#14

Adding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

Ask again with the specifics and you will get a better answer than this one.

42 17BethLabQueen, ChrisMacros, KetoKyle and 39 others
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Admin
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Aug 1, 2025 at 8:25 AM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Tagging this one for the weekly digest.

Last edited: Aug 1, 2025 at 12:25 PM
41 16PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 38 others
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