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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMetabolic Health & DiabetesGot off metformin for the first time in 8 years - crying happy tears Page 3

Got off metformin for the first time in 8 years - crying happy tears

MikeKY_noInsulin Thu, May 14, 2026 at 9:54 AM 20 replies 653 viewsPage 3 of 4
HPLC_Greg
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May 16, 2026 at 11:08 PM#11
Dr.ReproEndo said:
Patient selection optimization for glycaemic control: emerging predictive biomarkers for GLP-1 agonist response include: Biomarker Association…

No disagreement, though it depends on where somebody is starting from, and this thread has been assuming a starting point nobody stated.

Last edited: May 17, 2026 at 5:08 AM
31 6SallyK_inj, CryptoCarl, MariaRD and 28 others
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roxy_nash
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May 17, 2026 at 1:09 AM#12
josh_phd_bmore said:
Fasting insulin is the lab my functional medicine doctor cares about most for glycaemic control: it's a much earlier marker of metabolic dysfunction…

Genuinely useful, thank you. I had the facts and not the framework.

Last edited: May 17, 2026 at 7:09 AM
30 5roxy_nash, tony_orlando, Dr.NephBHM_UK and 27 others
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Dr.EM_Chicago
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May 17, 2026 at 3:10 AM#13
Dr.ReproEndo said:
Patient selection optimization for glycaemic control: emerging predictive biomarkers for GLP-1 agonist response include: Biomarker Association…

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

Last edited: May 17, 2026 at 7:10 AM
29 4Dr.ReproEndo, lucas_SP_BR, lisa_labSD and 26 others
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DataDave
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May 17, 2026 at 5:11 AM#14

One concrete data point for the thread. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

28 3amsterdam_pete, LondonLisa, mike_nyc and 25 others
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Admin
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May 17, 2026 at 7:12 AM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Thread quality here is what the rules are for. Keep it up.

27 2PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 24 others
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