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ForumsPharmacology & MechanismsEnteroendocrine L-cell biology — what worked for you? Page 3

Enteroendocrine L-cell biology — what worked for you?

ZaraB_AL Fri, Mar 6, 2026 at 4:18 AM 11 replies 925 viewsPage 3 of 3
Dr.NateNeph
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Mar 7, 2026 at 8:09 AM#11
TrialNerd_Beth said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.

17 15JakeSmashed95, NauseaFreeNow, SteveThurs and 14 others
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JakeBK_lifts
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Mar 8, 2026 at 5:28 AM#12
KarenAZ_mom said:
The pharmacokinetics explain nearly every practical question asked here.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Adding it to my notes with a link back to this thread.

Last edited: Mar 8, 2026 at 7:28 AM
18 16JennaRN, LabKate, kate.chem and 15 others
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Dr.ReproEndo
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Mar 9, 2026 at 2:46 AM#13
TrialNerd_Beth said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

19 17Dr.EndoEP, GraceAZ_72, carl_compliance and 16 others
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DanielChem_CHI
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Mar 10, 2026 at 12:04 AM#14

The figures, for anyone assembling their own picture. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

20 18ben_calgary, patPC_UT, Dr.DermMIA and 17 others
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Admin
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Mar 10, 2026 at 9:21 PM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out.

Last edited: Mar 11, 2026 at 1:21 AM
21 19PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 18 others
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