Dr.ReproEndo said:The shortage clause is the answer to the second question and it is a subtraction rather than an addition.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
wanda_boise said:The mechanism that matters here is not stomach emptying, it is central.
Thank you — that is the clearest version of this I have read, and I have read a lot of them. Taking it to my next appointment.
Dr.ReproEndo said:The shortage clause is the answer to the second question and it is a subtraction rather than an addition.
I will push back on the "any working dose is fine" framing. The maintenance evidence sits overwhelmingly at the top studied dose, and the extension data shows regain tracking dose reduction rather than tracking stopping. Holding low is reasonable; pretending it is evidentially equivalent is not.
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Browse GL BiochemAdding the numbers, since they settle part of this. Two things anyone can check: a state licence number for a 503A, and an FDA outsourcing-facility registration for a 503B. Both are publicly searchable, and a pharmacy unwilling to give you either has answered the question.