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Evidence-based GLP-1 & peptide discussion since 2023
ForumsDosing & ProtocolsHas anyone dealt with i missed my shot day by 2 days am i going to be okay?

Has anyone dealt with i missed my shot day by 2 days am i going to be okay?

JakeSmashed95 Tue, Apr 15, 2025 at 11:49 PM 25 replies 1,966 viewsPage 1 of 5
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JakeSmashed95
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Apr 15, 2025 at 11:49 PM#1

This gets cited here weekly, usually second-hand, so it is worth setting out what it does and does not establish.

Holding longer is the underrated move. A step that is uncomfortable at week two is frequently comfortable at week six with no change in dose, because the gastric-emptying component tachyphylaxes while the appetite effect persists. Escalating at week two throws that adaptation away.

Where I think it is weakest: the subgroup findings are the part I trust least — with enough subgroups something is always significant, and these were not all pre-registered.

What would genuinely help is knowing what the trials actually did with participants who could not tolerate a step, because that is the situation I am in and the protocol summaries skip it. Happy to be told the question itself is wrong.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
7 2Dr.PainCLE, mike_mealprep, NicoleRaleigh and 4 others
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Dr.SleepRoch
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Apr 15, 2025 at 11:54 PM#2
JakeSmashed95 said:
A step that is uncomfortable at week two is frequently comfortable at week six with no change in dose, because the gastric-emptying component…

Agreeing with JakeSmashed95, and the qualification matters more than the agreement. The trials generally allowed a step to be held or reduced and then retried, and people who did that mostly arrived at the same place a few weeks later. The end point of the ladder is set by tolerability, not by a schedule, and there is no evidence that reaching the top faster produces a better outcome.

6 1kim_atl_prep, sarah_TO, wendy_avl and 3 others
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sarah.morrison
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Apr 15, 2025 at 11:59 PM#3
JakeSmashed95 said:
A step that is uncomfortable at week two is frequently comfortable at week six with no change in dose, because the gastric-emptying component…

I disagree that the ladder is purely tolerability. The maintenance and regain data cluster at the top doses, so a ladder abandoned halfway leaves you outside the evidence base for the part that matters most — keeping it off.

5 0tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 2 others
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PharmacoVig_BOS
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Apr 16, 2025 at 12:04 AM#4

Short answer first, then the reasoning. Four weeks is the pharmacokinetics, not caution. With a one-week half-life you need four to five half-lives to reach steady state, so at two weeks you are dosing on top of a concentration that has not finished rising. Escalating then stacks exposure and you get the side-effect burden of the higher dose before you have seen the benefit of the current one.

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FitDadDave
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Apr 16, 2025 at 12:29 AM#5
Dr.SleepRoch said:
The trials generally allowed a step to be held or reduced and then retried, and people who did that mostly arrived at the same place a few weeks…

Mine went the same way, slower.

3 23jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner
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