Dr.RenalNash said:

Alcohol relationship change with food noise: I used to drink 3-4 beers most nights.

The GLP-1 and alcohol use disorder connection, relevant to food noise: observational data from Scandinavian registries shows reduced alcohol-related hospitalizations in GLP-1 agonist users[1].

The mechanism is plausible: GLP-1R is expressed in the mesolimbic reward pathway (VTA, nucleus accumbens). Agonism at these receptors may reduce the reinforcing properties of alcohol, similar to the reduction in "food noise."

RCTs for GLP-1 agonists in AUD are now underway. If positive, this would be a paradigm-shifting repurposing of existing medications.

maya_sedona said:

"Food aversion" side effect of food noise that I wasn't prepared for: I used to LOVE cooking and trying new restaurants.

That reframing is the part I needed. Sending this to two other people who asked me the same thing last week.

Dr.RenalNash said:

Alcohol relationship change with food noise: I used to drink 3-4 beers most nights.

Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.

The figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source.