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ForumsDosing & ProtocolsMicro-dosing semaglutide — what worked for you? Page 2

Micro-dosing semaglutide — what worked for you?

Dr.NateNeph Sat, Feb 22, 2025 at 9:06 AM 18 replies 1,612 viewsPage 2 of 4
claudia_zurich
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Feb 22, 2025 at 10:36 PM#6

Quick practical note — if you're doing 0.125mg from a compounded vial, the reconstitution math matters a lot here. With a 5mg vial:

  • Add 2mL BAC water → 2.5mg/mL → 0.125mg = 0.05mL = 5 units

5 units on an insulin syringe is a very small amount — just be sure you're using a syringe with fine enough markings. A 0.3mL (30-unit) syringe will have individual unit markings and be much easier to read accurately at this volume than a full 1mL syringe.

Last edited: Feb 23, 2025 at 4:36 AM
2 22emma_london, tammy_FL
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VanRx_Mike
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Vancouver, CA
Feb 23, 2025 at 3:57 AM#7

Great call on the syringe. I'll order the 0.3mL ones. Thank you for the advice! 🙏

1 21MikeNYC_runner
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Admin
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Feb 23, 2025 at 9:18 AM#8

Good discussion. I'll just add the standard disclaimer that micro-dosing is off-label and should be done under provider supervision. We don't want anyone reading this thread and deciding to start at a random low dose without medical guidance. Your provider can factor in your full medical history, not just your weight.

Last edited: Feb 23, 2025 at 1:18 PM
50 20RegAffairsDC, BiostatsBrad, PeptideSynthNJ and 47 others
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