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ForumsPharmacology & MechanismsStructure-activity relationships of GLP-1 analogs — looking for input Page 3

Structure-activity relationships of GLP-1 analogs — looking for input

pat_auckland Sun, Dec 28, 2025 at 9:12 PM 11 replies 949 viewsPage 3 of 3
GraceAZ_72
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Jan 5, 2026 at 10:03 AM#11
rachel_ABQ said:
Semaglutide structural biology relevant to the pharmacology: semaglutide is a 31-amino acid peptide with 94% homology to native GLP-1(7-36).

This is exactly what I could not find anywhere else.

18 16MariaRD, AussieAnna, BethLabQueen and 15 others
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Dr.EndoEP
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Jan 7, 2026 at 5:20 AM#12

Clinical perspective, offered as context rather than as advice. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

19 17james_edin, FranDenver, Dr.BariatricHTX and 16 others
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Dr.NateNeph
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Jan 9, 2026 at 12:36 AM#13
LindaRN_retired said:
I want to add the drug interaction perspective on the pharmacology.

Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.

20 18SteveThurs, B12Beth, RickReta_CO and 17 others
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PharmacoVig_BOS
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Jan 10, 2026 at 7:51 PM#14

Adding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

Last edited: Jan 10, 2026 at 10:51 PM
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mike_mod
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Jan 12, 2026 at 3:05 PM#15

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here.

22 20PurityPaulOR, MaxMetOK, MounjBrad and 19 others
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