paige_pharma said:The pharmacokinetics explain nearly every practical question asked here.
Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were relying on physical fullness feel the effect fade while the appetite effect is still working.
kim_atl_prep said:Agreed on the mechanism, with the caveat that the head-to-head used semaglutide 1mg, not 2.4mg.
This answered a question I did not know how to ask. I will report back once I have actually tried it.
paige_pharma said:The pharmacokinetics explain nearly every practical question asked here.
Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.
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Moderator note: the sourcing question belongs in the vendor section and has been split out. Carry on.