🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsOff-TopicBook club — currently reading "Ultraprocessed People" by Chris van Tulleken

Book club — currently reading "Ultraprocessed People" by Chris van Tulleken

LibrarianMeg Mon, May 11, 2026 at 10:16 PM 8 replies 550 viewsPage 1 of 2
LibrarianMeg
Senior Member
1,678
7,890
Mar 2024
Baltimore, MD
May 11, 2026 at 10:16 PM#1

Splitting this out of the general thread because the answers kept arriving in ones and twos and nobody could see the shape of it.

The thing that changed for me was not hunger, it was that the constant background negotiation about food simply stopped, and I had not realised it was constant until it was not.

The narrow version of the question is whether the quiet is the same mechanism as the appetite suppression or a separate one, because they seem to come and go on different schedules.

Roughly, people seem to land in one of these:

  • Held where they were and waited it out
  • Changed one variable and kept everything else fixed
  • Changed several things at once and cannot now attribute the result
  • Stopped and reassessed from a clean baseline

Say which and say why — the why is the useful half.

35 5Dr.NateNeph, PharmD_Rodriguez, julia.endo and 32 others
Reply Quote Save Share Report
LipidDoc_ATL
Senior Member
1,123
5,678
Apr 2024
Atlanta, GA
May 11, 2026 at 10:53 PM#2
LibrarianMeg said:
The thing that changed for me was not hunger, it was that the constant background negotiation about food simply stopped, and I had not realised it was…

"Food aversion" side effect of food noise that I wasn't prepared for: I used to LOVE cooking and trying new restaurants. Now certain foods — especially heavy cream sauces — literally repulse me.

It's not just reduced appetite; it's an active disgust response. My therapist says this is common and likely related to the reward pathway modulation. It's mostly a positive change, but I do miss enjoying food the way I used to.

34 4traveltech_sara, AttorneyGrant, DebRD_ATL and 31 others
Reply Quote Save Share Report
DadBodDave
Member
187
923
Nov 2024
Ohio
May 11, 2026 at 11:30 PM#3
LipidDoc_ATL said:
"Food aversion" side effect of food noise that I wasn't prepared for: I used to LOVE cooking and trying new restaurants.

Neuroscience perspective on food noise:

GLP-1 receptors are expressed throughout the CNS, with high density in the hypothalamic arcuate nucleus, area postrema, and — critically — the mesolimbic reward pathway[1].

This is directly relevant to food noise because the central effects of GLP-1 agonists extend far beyond simple appetite suppression. The reduction in "food noise" that patients describe is likely mediated by modulation of dopaminergic signaling in the VTA and nucleus accumbens.

The emerging data on reduced addictive behaviors (alcohol, gambling) further supports this mechanism. food noise should be understood in this broader neurobiological context.

References:
[1] Merchenthaler I, et al. J Comp Neurol. 1999;403(2):261-280.
Last edited: May 12, 2026 at 2:30 AM
33 3pat_auckland, Dr.GastroMayo, JakeBK_lifts and 30 others
Reply Quote Save Share Report

Janoshik Analytical — Independent Testing

Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.

Verify Your Peptides

GL Biochem (Shanghai) Ltd. — Direct Manufacturer

Est. 1998. The synthesis house behind the vials you send for testing. ISO 9001 and cGMP certified, 1,500+ staff, batch-specific COA with every order.

Browse GL Biochem
chris_chi24
Member
389
1,678
Sep 2024
Chicago, IL
May 12, 2026 at 12:07 AM#4
LibrarianMeg said:
The thing that changed for me was not hunger, it was that the constant background negotiation about food simply stopped, and I had not realised it was…

This matches mine closely enough to be worth saying so out loud. Nothing to add that would improve it.

32 2PurityPaulOR, MaxMetOK, MounjBrad and 29 others
Reply Quote Save Share Report
BariatricNurseD
Senior Member
1,678
7,234
Feb 2024
Dallas, TX
Online
May 12, 2026 at 3:35 AM#5

Clinical perspective, offered as context rather than as advice.

Phantom hunger vs real hunger on food noise: learning to distinguish between the two has been a revelation. Real hunger: gradual onset, physical stomach sensation, any food sounds good. Phantom hunger: sudden, emotionally triggered, specific food cravings, occurs right after eating.

The GLP-1 agonist suppresses real hunger beautifully. Phantom hunger still pops up but I can now recognize it for what it is — an emotional signal, not a physical need. Mindfulness training helped enormously with this distinction.

Last edited: May 12, 2026 at 8:35 AM
31 1Dr.EndoIndy, tom_AK, josh_phd_bmore and 28 others
Reply Quote Save Share Report

Similar Threads

What are you cooking tonight? (High protein edition)9 replies
Fitness tracker recommendations — beyond step counting10 replies
Books that changed your relationship with food17 replies
Air fryer recipes thread — quick high-protein meals23 replies
What does your shot day routine look like?6 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register