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ForumsPharmacology & MechanismsWhy does it stop working after a while for some people — anyone have experience? Page 8

Why does it stop working after a while for some people — anyone have experience?

kim_atl_prep Thu, Sep 18, 2025 at 5:27 PM 38 replies 2,109 viewsPage 8 of 8
Dr.ReproEndo
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Oct 1, 2025 at 11:01 PM#36
Dr.NephBHM_UK said:
The version of this that has an answer is narrower than the version being asked.

Coming at Dr.NephBHM_UK’s question from a different direction. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

35 8mona_PHX, andrew_nyc, Dr.EndoEP and 32 others
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BiostatsBrad
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Oct 2, 2025 at 2:44 PM#37

The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

Last edited: Oct 2, 2025 at 3:44 PM
36 9Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 33 others
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JakeSmashed95
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Oct 3, 2025 at 6:26 AM#38

A narrower follow-up, since the general answer is now clear:

What would you measure differently if you were starting again?

37 10alex_tucson, kevin_tulsa, Dr.PainCLE and 34 others
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FDA_TrackerJim
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Oct 3, 2025 at 10:08 PM#39
BiostatsBrad said:
If you are going to change something, change one thing and give it long enough to express itself.

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

Last edited: Oct 4, 2025 at 1:08 AM
38 11Dr.LeslieOBGYN, MikeNYC_runner and 35 others
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JakeBK_lifts
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Oct 4, 2025 at 1:49 PM#40
BiostatsBrad said:
If you are going to change something, change one thing and give it long enough to express itself.

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

10 8DataDave, Dr.GutHealth, amsterdam_pete and 7 others
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