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ForumsPharmacology & MechanismsGLP-1R desensitization — 12 month update Page 7

GLP-1R desensitization — 12 month update

WendyG_ATL Sat, Aug 16, 2025 at 8:18 AM 40 replies 1,750 viewsPage 7 of 8
PeptideChemSF
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Aug 22, 2025 at 8:13 PM#31
GenomicsKate said:
The distinction that resolves most of these threads is between what is true on average and what is true for one person.

There is a second half to this that has not been said yet. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

47 20steve_okc, dave_SLC, FDA_TrackerJim and 44 others
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Dr.NateNeph
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Aug 23, 2025 at 5:25 AM#32

The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

48 21NauseaFreeNow, SteveThurs, B12Beth and 45 others
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SaraMom3
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Aug 23, 2025 at 2:37 PM#33

A narrower follow-up, since the general answer is now clear:

What would you measure differently if you were starting again?

49 22KetoKyle, CanadaChris, ZaraB_AL and 46 others
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RickReta_CO
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Aug 23, 2025 at 11:48 PM#34
Dr.NateNeph said:
If you are going to change something, change one thing and give it long enough to express itself.

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

50 23tommy_boulder, hyun_seoul, jim_asheville and 47 others
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marcus_mpls
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Aug 24, 2025 at 8:59 AM#35
Dr.NateNeph said:
If you are going to change something, change one thing and give it long enough to express itself.

Agreeing with Dr.NateNeph, and the qualification matters more than the agreement. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.

1 24mona_PHX
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