Following on from PharmD_Rodriguez — and this may be the naive question:

How much of the oral variability is the SNAC absorption window and how much is dose, because the two get conflated constantly?

cory_ATX said:

The useful move here is to separate what is established from what is widely repeated.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

cory_ATX said:

The useful move here is to separate what is established from what is widely repeated.

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

Happy to go further on any of that.

cory_ATX said:

The useful move here is to separate what is established from what is widely repeated.

Genuinely useful, thank you. I had the facts and not the framework. I will report back once I have actually tried it.

Adding the clinical framing, because it changes how the question reads. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

I would rather be corrected than agreed with, if it comes to it.