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ForumsPharmacology & MechanismscAMP signaling cascade from GLP-1R activation — 12 month update Page 3

cAMP signaling cascade from GLP-1R activation — 12 month update

FitDadDave Wed, Jun 4, 2025 at 2:41 PM 25 replies 1,558 viewsPage 3 of 5
anders_CPH
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Jun 11, 2025 at 9:14 PM#11
chris_chi24 said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

1 24CryptoCarl
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greg_boulder
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Jun 13, 2025 at 1:45 PM#12
LeilaHI said:
The pharmacokinetics explain nearly every practical question asked here.

This is exactly what I could not find anywhere else. Taking it to my next appointment.

Last edited: Jun 13, 2025 at 3:45 PM
2 0fiona_VT, denise_HTX
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dan_philly
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Jun 15, 2025 at 6:15 AM#13
chris_chi24 said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

3 1SkepticalSean, Dr.CardioMD, EndoResFellow
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HPLC_Greg
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Jun 16, 2025 at 10:44 PM#14

The figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Last edited: Jun 17, 2025 at 4:44 AM
4 2Dr.MetabolicMD, RetaRick_CA, JenPlateau and 1 other
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mike_mod
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Jun 18, 2025 at 3:12 PM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part.

5 3PurityPaulOR, MaxMetOK, MounjBrad and 2 others
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