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ForumsOral GLP-1 AgonistsOrforglipron Phase 3 ATTAIN-1 topline — oral non-peptide GLP-1 Page 3

Orforglipron Phase 3 ATTAIN-1 topline — oral non-peptide GLP-1

TrialTracker_MD Mon, Jun 8, 2026 at 8:45 AM 16 replies 288 viewsPage 3 of 4
KristenIndy
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Jun 8, 2026 at 10:16 AM#11
Dr.KarenChen said:
The manufacturing argument is the underrated one.

That reframing is the part I needed. Printing the relevant bit and taking it with me.

Last edited: Jun 8, 2026 at 3:16 PM
7 5LondonLisa, mike_nyc, VendorMark and 4 others
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PharmHunterJen
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Jun 8, 2026 at 11:40 AM#12

From the other side of the consultation, briefly. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.

8 6alex_tucson, kevin_tulsa, Dr.PainCLE and 5 others
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PharmacoVig_BOS
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Jun 8, 2026 at 1:03 PM#13
Dr.EndoEP said:
Relative and absolute effects need reading together.

I read this differently from Dr.EndoEP, on substance rather than tone. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.

9 7DataDave, Dr.GutHealth, amsterdam_pete and 6 others
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SleepDoc_PDX
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Portland, OR
Jun 8, 2026 at 2:27 PM#14

Adding the numbers, since they settle part of this. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

Last edited: Jun 8, 2026 at 5:27 PM
10 8sophie_paris, mel_PDX, Dr.AddMedPHL and 7 others
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Admin
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Jun 8, 2026 at 3:50 PM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Carry on.

Last edited: Jun 8, 2026 at 7:50 PM
11 9PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 8 others
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