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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsPeptide degradation pathways — my results so far Page 3

Peptide degradation pathways — my results so far

MeganSA_TX Tue, May 6, 2025 at 6:48 AM 15 replies 1,663 viewsPage 3 of 3
labquiet_amy
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May 9, 2025 at 11:41 PM#11
MASHdoc_SA said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

MASHdoc_SA has the substance of this right. The condition it depends on is worth stating. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.

Last edited: May 10, 2025 at 1:41 AM
2 0TrialNerd_Beth, HPLC_Greg
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RegAffairsDC
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May 12, 2025 at 4:46 PM#12
PurityPaulOR said:
The pharmacokinetics explain nearly every practical question asked here.

Genuinely useful, thank you. I had the facts and not the framework.

Last edited: May 12, 2025 at 6:46 PM
3 1Dr.SportsMedIN, amy_econ_NJ, bbq_ray_KC
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PharmacoVig_BOS
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May 15, 2025 at 9:49 AM#13
MASHdoc_SA said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

This is where I part company with the consensus forming above. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.

Last edited: May 15, 2025 at 12:49 PM
4 2DataDave, Dr.GutHealth, amsterdam_pete and 1 other
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Dr.NateNeph
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May 18, 2025 at 2:51 AM#14

The figures, for anyone assembling their own picture. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

Happy to go further on any of that.

Last edited: May 18, 2025 at 4:51 AM
5 3B12Beth, RickReta_CO, PharmHunterJen and 2 others
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Admin
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May 20, 2025 at 7:52 PM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Report rather than reply if it drifts again.

6 4PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 3 others
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