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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsHas anyone dealt with molecular dynamics simulations of glp-1r binding? Page 4

Has anyone dealt with molecular dynamics simulations of glp-1r binding?

BrianDallas92 Wed, Apr 16, 2025 at 2:37 AM 36 replies 1,942 viewsPage 4 of 8
MounjBrad
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May 3, 2025 at 9:08 AM#16
MASHdoc_SA said:
Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

Same experience, arrived at from the opposite direction. Nothing to add that would improve it.

45 18patPC_UT, Dr.DermMIA, fiona_VT and 42 others
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LarryQC_SD
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May 6, 2025 at 2:31 AM#17
hank_denver said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Sending this to two other people who asked me the same thing last week.

Last edited: May 6, 2025 at 3:31 AM
46 19paul_denver, TinaHashiRN, robert_kc and 43 others
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anna.melb_AU
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May 8, 2025 at 7:53 PM#18

Adding the clinical framing, because it changes how the question reads. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.

47 20emma_london, tammy_FL, Dr.LipidDallas and 44 others
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NurseKim_ATL
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May 11, 2025 at 1:13 PM#19
anna.melb_AU said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

Can confirm. Same sequence, different timescale. The detail I would add is minor and it is already implied above.

Last edited: May 11, 2025 at 6:13 PM
48 21pete_nash, hank_denver, carlos_SATX and 45 others
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May 14, 2025 at 6:32 AM#20

Moderator note: a couple of off-topic posts removed. No action needed from anybody.

20 18PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 17 others
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