The figures, for anyone assembling their own picture. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.
One thing that is still open after Dr.RaviCardio’s answer:
Whether the fasting requirement is as strict in practice as the label implies, and what people actually see when they get it wrong?
BiostatsBrad said:The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…
There is a second half to this that has not been said yet. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.
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View ResultsOP back with an update, since a thread like this is useless without one.
Follow-up: moving the tablet to the moment I wake, before anything else, was the whole fix. The dose never changed.
SarahChen_PharmD said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
That is correct as far as it goes, and here is where it stops going. The absorption variability is real, but it partly averages out over weeks — the steady-state trough is less erratic than any single day would suggest. Where it bites is in the first fortnight, when people conclude the tablet does nothing.