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ForumsOral GLP-1 AgonistsOrforglipron and hepatic first-pass metabolism Page 4

Orforglipron and hepatic first-pass metabolism

SarahChen_PharmD Thu, Jun 4, 2026 at 7:28 AM 22 replies 441 viewsPage 4 of 5
SandraNC_45
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Jun 5, 2026 at 4:51 AM#16
Dr.ReproEndo said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Same experience, arrived at from the opposite direction. Nothing to add that would improve it.

Last edited: Jun 5, 2026 at 9:51 AM
26 24FranDenver, Dr.BariatricHTX, LindaRN_retired and 23 others
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newstart_MO
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Jun 5, 2026 at 8:20 AM#17

Adding the clinical framing, because it changes how the question reads. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.

27 0LibrarianMeg, bri_stats, pete_manc_UK and 24 others
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mark_tokyo
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Jun 5, 2026 at 11:49 AM#18
newstart_MO said:
It helps to ask what evidence would change your mind before you look at any.

This is my experience too, for whatever a second data point is worth.

Last edited: Jun 5, 2026 at 2:49 PM
28 1LibrarianMeg, bri_stats, pete_manc_UK and 25 others
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LindaRN_retired
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Jun 5, 2026 at 3:18 PM#19
newstart_MO said:
It helps to ask what evidence would change your mind before you look at any.

Coming at newstart_MO’s question from a different direction. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

Last edited: Jun 5, 2026 at 6:18 PM
29 2LondonLisa, mike_nyc, VendorMark and 26 others
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mike_mod
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Jun 5, 2026 at 6:46 PM#20

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Tagging this one for the weekly digest.

Last edited: Jun 5, 2026 at 8:46 PM
1 24PurityPaulOR
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