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ForumsOral GLP-1 AgonistsSmall molecule vs peptide GLP-1 agonists — binding affinity comparison Page 3

Small molecule vs peptide GLP-1 agonists — binding affinity comparison

PeptideChemSF Sun, May 31, 2026 at 5:43 PM 16 replies 583 viewsPage 3 of 4
jason_paloalto
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Jun 1, 2026 at 5:39 AM#11
Dr.SurgeonPGH said:
Orforglipron is the more interesting oral story because it is not a peptide at all.

Thank you for spelling out the reasoning rather than just the conclusion. I will report back once I have actually tried it.

Last edited: Jun 1, 2026 at 10:39 AM
4 2tane_welly, Dr.PathRoch, mona_PHX and 1 other
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claudia_zurich
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Jun 1, 2026 at 11:19 AM#12

Clinical perspective, offered as context rather than as advice. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

5 3tammy_FL, Dr.LipidDallas, alex_tucson and 2 others
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Dr.ObesityMed
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Jun 1, 2026 at 4:59 PM#13
TinaHashiRN said:
It helps to say which part of this you are uncertain about.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

Last edited: Jun 1, 2026 at 10:59 PM
6 4SurmountFan_IN, PeptideChemSF, A1cHero_PHX and 3 others
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Dr.PathRoch
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Jun 1, 2026 at 10:39 PM#14

The figures, for anyone assembling their own picture. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Ask again with the specifics and you will get a better answer than this one.

7 5SaraMom3, Dr.MetabolicMD, RetaRick_CA and 4 others
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mike_mod
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Jun 2, 2026 at 4:19 AM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Thread quality here is what the rules are for. Keep it up.

Last edited: Jun 2, 2026 at 6:19 AM
8 6PurityPaulOR, MaxMetOK, MounjBrad and 5 others
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