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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOff-TopicHas anyone dealt with glp-1 and your career?

Has anyone dealt with glp-1 and your career?

TrialTracker_MD Sun, Dec 21, 2025 at 8:46 PM 11 replies 998 viewsPage 1 of 3
TrialTracker_MD
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Dec 21, 2025 at 8:46 PM#1

The thing that changed for me was not hunger, it was that the constant background negotiation about food simply stopped, and I had not realised it was constant until it was not.

What would genuinely help is knowing whether the quiet is the same mechanism as the appetite suppression or a separate one, because they seem to come and go on different schedules.

Numbers rather than impressions, if you have them.

21 16Dr.EM_Chicago, pete_RVA, CarlaRPh_TPA and 18 others
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PharmD_Rodriguez
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Dec 21, 2025 at 8:57 PM#2
TrialTracker_MD said:
The thing that changed for me was not hunger, it was that the constant background negotiation about food simply stopped, and I had not realised it was…

"Food aversion" side effect of food noise that I wasn't prepared for: I used to LOVE cooking and trying new restaurants. Now certain foods — especially red meat — literally repulse me.

It's not just reduced appetite; it's an active disgust response. My therapist says this is common and likely related to the reward pathway modulation. It's mostly a positive change, but I do miss enjoying food the way I used to.

20 15TinaHashiRN, robert_kc, dan_philly and 17 others
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pete_nash
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Dec 21, 2025 at 9:08 PM#3
PharmD_Rodriguez said:
"Food aversion" side effect of food noise that I wasn't prepared for: I used to LOVE cooking and trying new restaurants.

Rebound hunger after missed dose of food noise: I missed my injection by 3 days due to a shipping delay and the hunger came ROARING back. Like a switch flipped. It was eye-opening to feel the difference.

This experience actually reinforced my understanding of what the medication does — it's not just "suppressing appetite," it's normalizing dysregulated hunger signaling. When the drug wears off, you feel the full force of what it was managing.

19 14mike_mod, SarahChen_PharmD, sarah.morrison and 16 others
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Dr.LeslieOBGYN
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Dec 21, 2025 at 9:19 PM#4
TrialTracker_MD said:
The thing that changed for me was not hunger, it was that the constant background negotiation about food simply stopped, and I had not realised it was…

Same pattern here, and in the same order.

Last edited: Dec 22, 2025 at 3:19 AM
18 13NicoleRaleigh, james_edin, FranDenver and 15 others
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VanRx_Mike
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Dec 21, 2025 at 10:19 PM#5

From the other side of the consultation, briefly.

Alcohol relationship change with food noise: I used to drink 3-4 beers most nights. Since starting GLP-1 therapy, I have zero interest in alcohol. Haven't had a drink in 11 months.

The "food noise" reduction seems to extend to other reward-seeking behaviors, including alcohol. My liver enzymes have improved, my sleep is better, and I've saved roughly $181/month on alcohol. Triple win.

17 12mike_mod, SarahChen_PharmD, sarah.morrison and 14 others
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