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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMetabolic Health & DiabetesRemission of T2DM on GLP-1 — 12 month update Page 2

Remission of T2DM on GLP-1 — 12 month update

Dr.GutHealth Mon, Jun 23, 2025 at 8:46 PM 10 replies 1,360 viewsPage 2 of 2
raj_cambridge
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Jun 24, 2025 at 3:20 AM#6
Dr.GutHealth said:
HbA1c reflects roughly three months of average glycaemia weighted toward the most recent weeks, which is why repeating it at six weeks tells you very…

My labs after 6 months on glycaemic control: A1C 6.0%, fasting glucose 80 mg/dL, fasting insulin 5 uIU/mL. My endo says these are "textbook perfect."

For context, my baseline A1C was 7.5% and fasting glucose was 135 mg/dL. The improvement has been dramatic and consistent.

Last edited: Jun 24, 2025 at 4:20 AM
28 23SleepFixSam, PurityPaulOR, MaxMetOK and 25 others
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SteveThurs
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Jun 24, 2025 at 5:55 AM#7

One thing that is still open after Dr.NateNeph’s answer:

Did your prescriber agree with that reading, and if not what was their objection?

27 22PurityPaulOR, MaxMetOK, MounjBrad and 24 others
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TinaHashiRN
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Raleigh, NC
Jun 24, 2025 at 8:30 AM#8
raj_cambridge said:
My labs after 6 months on glycaemic control: A1C 6.0%, fasting glucose 80 mg/dL, fasting insulin 5 uIU/mL.

Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone:

TestBaselineMonth 3Month 6Month 12
Glucose (fasting)1261089086
Insulin (fasting)2216106
HOMA-IR4.53.21.81.5
Uric Acid7.96.65.75.2

The insulin resistance improvement (HOMA-IR) is what my endo focuses on most. Going from 4.5 to near 1.0 is a metabolic transformation.

Last edited: Jun 24, 2025 at 2:30 PM
26 21Dr.Martinez, mike_mod, SarahChen_PharmD and 23 others
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Dr.GutHealth
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Jun 24, 2025 at 11:05 AM#9
raj_cambridge said:
My labs after 6 months on glycaemic control: A1C 6.0%, fasting glucose 80 mg/dL, fasting insulin 5 uIU/mL.

Insulin sensitivity test (HOMA-IR) on glycaemic control — arguably the most important metabolic marker most people aren't tracking:

HOMA-IR = (fasting insulin × fasting glucose) ÷ 405

My numbers: Baseline HOMA-IR = 4.6 (insulin resistant) → Current = 1.2 (insulin sensitive)

Anything above 2.0 indicates insulin resistance. The goal is below 1.5. GLP-1 agonists address the root metabolic dysfunction, not just the symptoms. This is why they work so much better than calorie restriction alone.

25 20Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 22 others
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Dr.EndoEP
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Jun 24, 2025 at 11:31 PM#10
TinaHashiRN said:
Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone: Test Baseline Month 3 Month 6 Month 12…

Fasting insulin is the lab my functional medicine doctor cares about most for glycaemic control: it's a much earlier marker of metabolic dysfunction than glucose or A1C.

My fasting insulin: 22 → 12 → 7 uIU/mL over 9 months. Target is <7. By the time your fasting glucose is elevated, your insulin has been elevated for YEARS trying to compensate.

Ask your doctor to include fasting insulin in your bloodwork panel. It's cheap (~$20) and incredibly informative.

49 22LindaRN_retired, tommy_boulder, hyun_seoul and 46 others
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