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ForumsPharmacology & MechanismsBiased agonism at GLP-1R — 12 month update Page 3

Biased agonism at GLP-1R — 12 month update

pam_columbus Tue, Dec 17, 2024 at 6:06 AM 52 replies 2,746 viewsPage 3 of 11
DanielChem_CHI
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Dec 22, 2024 at 8:55 PM#11
CarlaRPh_TPA said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

No disagreement, though it depends on where somebody is starting from, and this thread has been assuming a starting point nobody stated.

1 24fiona_VT
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SandraNC_45
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Dec 25, 2024 at 7:13 PM#12
RegAffairsDC said:
The mechanism is more central than most summaries suggest.

Bookmarking. The distinction being drawn above is the one nobody else makes.

2 0james_edin, FranDenver
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MarkLI_maint
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Dec 28, 2024 at 5:29 PM#13
CarlaRPh_TPA said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Pushing back on the consensus forming here. Consistency is not the same as correctness, and a board that agrees with itself quickly is usually agreeing with the first person who sounded certain.

3 1HPLC_Greg, LibrarianMeg, bri_stats
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raj_cambridge
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Dec 31, 2024 at 3:43 PM#14

Adding the numbers, since they settle part of this. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

4 2PharmHunterJen, TomTeleRx, DoseLogDan and 1 other
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mike_mod
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Jan 3, 2025 at 1:56 PM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. No action needed from anybody.

Last edited: Jan 3, 2025 at 3:56 PM
5 3PurityPaulOR, MaxMetOK, MounjBrad and 2 others
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