DeniseRN_TPA said:

The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

True, and it depends on a baseline nobody has stated. Without knowing where someone started, the same number can be an excellent result or a disappointing one.

GenomicsKate said:

Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were…

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Sending this to two other people who asked me the same thing last week.

DeniseRN_TPA said:

The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Pushing back on DeniseRN_TPA here. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

One concrete data point for the thread. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Carry on.