Dr.SportsMedIN said:

Oral semaglutide is absorbed in the stomach with the help of SNAC, which locally raises pH and protects the peptide long enough to cross.

I do not accept that the fasting window is a minor inconvenience. Adherence data on daily orals with timing requirements is consistently worse than weekly injections, and a drug you take imperfectly is a lower dose than the one on the box.

Happy to go further on any of that.

One concrete data point for the thread. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

KevinCompounds said:

I do not accept that the fasting window is a minor inconvenience.

There is a second half to this that has not been said yet. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

That is the short version; the long version is somebody else's post.

One thing that is still open after hank_denver’s answer:

How much of the oral variability is the SNAC absorption window and how much is dose, because the two get conflated constantly?

Closing the loop on my own question.

Update — I went back to the injectable. Not because the tablet did not work, but because the fasting window and my mornings were never going to agree.