Adding the clinical framing, because it changes how the question reads. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.
PeptideChemSF said:The mechanism and the magnitude are separate questions.
This is my experience too, for whatever a second data point is worth.
PeptideChemSF said:The mechanism and the magnitude are separate questions.
There is a second half to this that has not been said yet. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.
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Browse GL BiochemOne concrete data point for the thread. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.
A narrower follow-up, since the general answer is now clear:
What would you measure differently if you were starting again?