NurseLeah_Nash said:

Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.

traveltech_sara said:

Agreed on the mechanism, with the caveat that the head-to-head used semaglutide 1mg, not 2.4mg.

Saving this. It is the first explanation that did not require me to already understand it. Adding it to my notes with a link back to this thread.

NurseLeah_Nash said:

Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

I read this differently from NurseLeah_Nash, on substance rather than tone. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

That is the short version; the long version is somebody else's post.

Adding the numbers, since they settle part of this. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source.