Dr.GutHealth said:

The mechanism is more central than most summaries suggest.

Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were relying on physical fullness feel the effect fade while the appetite effect is still working.

I would rather be corrected than agreed with, if it comes to it.

CryptoCarl said:

True, though the ladder is longer and that is not a neutral detail — six dose steps means six opportunities to stall on the way up, and plenty of…

This answered a question I did not know how to ask.

Dr.GutHealth said:

The mechanism is more central than most summaries suggest.

Pushing back on Dr.GutHealth here. The counter-case has not been addressed. Somebody upthread described the situation that does not fit, and the thread moved on rather than engaging with it, which is the failure mode this board is supposed to avoid.

That is the short version; the long version is somebody else's post.

The figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. Tagging this one for the weekly digest.