🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsStructure-function of tirzepatide — 12 month update Page 7

Structure-function of tirzepatide — 12 month update

RunnerRach Thu, May 30, 2024 at 1:05 AM 50 replies 2,566 viewsPage 7 of 10
sarah.morrison
VIP Member
3,212
14,567
Jan 2024
California
Online
Jun 15, 2024 at 1:46 AM#31
PharmHunterJen said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

There is a second half to this that has not been said yet. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

Last edited: Jun 15, 2024 at 2:46 AM
1 24josh_phd_bmore
Reply Quote Save Share Report
dave_SLC
Member
345
1,567
Aug 2024
Salt Lake City, UT
Jun 16, 2024 at 5:06 AM#32

Adding the numbers, since they settle part of this. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

2 0NicoleRaleigh, james_edin
Reply Quote Save Share Report
labquiet_amy
Senior Member
1,234
6,789
Mar 2024
Cambridge, MA
Jun 17, 2024 at 8:25 AM#33

One thing that is still open after PharmHunterJen’s answer:

Was that from a primary source or from a summary of one?

3 1LibrarianMeg, bri_stats, pete_manc_UK
Reply Quote Save Share Report

Janoshik Analytical — Independent Testing

Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.

Verify Your Peptides

GL Biochem (Shanghai) Ltd. — Direct Manufacturer

Est. 1998. The synthesis house behind the vials you send for testing. ISO 9001 and cGMP certified, 1,500+ staff, batch-specific COA with every order.

Browse GL Biochem
MariaRD
Member
823
4,567
Jun 2024
New Mexico
Jun 18, 2024 at 11:44 AM#34
dave_SLC said:
If you are going to change something, change one thing and give it long enough to express itself.

I read this differently from dave_SLC, on substance rather than tone. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

That is the short version; the long version is somebody else's post.

Last edited: Jun 18, 2024 at 12:44 PM
4 2rick_sfbay, maria_elpaso, anders_CPH and 1 other
Reply Quote Save Share Report
amy_econ_NJ
Member
567
2,567
May 2024
Princeton, NJ
Jun 19, 2024 at 3:02 PM#35
dave_SLC said:
If you are going to change something, change one thing and give it long enough to express itself.

Right, and the exception is worth naming rather than left implied, because the exception is where people get into trouble.

That is the short version; the long version is somebody else's post.

Last edited: Jun 19, 2024 at 6:02 PM
5 3NurseLeah_Nash, gary_naperville, sean_dublin and 2 others
Reply Quote Save Share Report

Similar Threads

GLP-1R desensitization — β-arrestin-mediated internalization18 replies
Biased agonism at GLP-1R — Gs vs β-arrestin signaling balance13 replies
Semaglutide albumin binding and the C-18 fatty acid linker17 replies
GIP receptor pharmacology — why GIP agonism enhances GLP-113 replies
Glucagon receptor signaling — hepatic glycogenolysis and lipolysis16 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register