Adding the clinical framing, because it changes how the question reads. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

Adding the clinical framing, because it changes how the question reads. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

NurseAsh_DET said:

The mechanism and the magnitude are separate questions.

This is my experience too, for whatever a second data point is worth.

NurseAsh_DET said:

The mechanism and the magnitude are separate questions.

There is a second half to this that has not been said yet. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Carry on.