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ForumsOral GLP-1 AgonistsDanuglipron dose optimization — 12 month update Page 3

Danuglipron dose optimization — 12 month update

Dr.MetabolicMD Sat, Mar 14, 2026 at 8:45 PM 34 replies 1,534 viewsPage 3 of 7
Dr.ObesityMed
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Mar 16, 2026 at 1:44 AM#11
Dr.RenalNash said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

Agreeing with Dr.RenalNash, and the qualification matters more than the agreement. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.

43 18EndoResFellow, PharmacoVig_BOS, SurmountFan_IN and 40 others
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carlos_SATX
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Mar 17, 2026 at 4:13 AM#12
MikeKY_noInsulin said:
The absorption variability is real, but it partly averages out over weeks — the steady-state trough is less erratic than any single day would suggest.

Genuinely useful, thank you. I had the facts and not the framework.

42 17FranDenver, Dr.BariatricHTX, LindaRN_retired and 39 others
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wanda_boise
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Mar 18, 2026 at 6:41 AM#13
Dr.RenalNash said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

I read this differently from Dr.RenalNash, on substance rather than tone. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

Happy to go further on any of that.

41 16pam_columbus, nick_SD_fit, ben_calgary and 38 others
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labquiet_amy
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Mar 19, 2026 at 9:09 AM#14

One concrete data point for the thread. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Happy to go further on any of that.

40 15bri_stats, pete_manc_UK, anna.melb_AU and 37 others
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Admin
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Mar 20, 2026 at 11:36 AM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source.

39 14PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 36 others
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