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ForumsMetabolic Health & DiabetesGLP-1 and uric acid reduction — September 2026

GLP-1 and uric acid reduction — September 2026

marco_milano Tue, Sep 24, 2024 at 11:14 AM 8 replies 1,794 viewsPage 1 of 2
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marco_milano
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Sep 24, 2024 at 11:14 AM#1

A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

So the question, as narrowly as I can put it: why A1C lags the way it does, and what to look at in the meantime if you want to know sooner.

Numbers rather than impressions, if you have them.

7 2kevin_tulsa, Dr.PainCLE, mike_mealprep and 4 others
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sarah.morrison
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Sep 24, 2024 at 11:25 AM#2
marco_milano said:
A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

My labs after 3 months on glycaemic control: A1C 5.4%, fasting glucose 79 mg/dL, fasting insulin 8 uIU/mL. My endo says these are "textbook perfect."

For context, my baseline A1C was 7.3% and fasting glucose was 114 mg/dL. The improvement has been dramatic and consistent.

6 1roxy_nash, tony_orlando, Dr.NephBHM_UK and 3 others
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sarah_TO
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Sep 24, 2024 at 11:36 AM#3
sarah.morrison said:
My labs after 3 months on glycaemic control: A1C 5.4%, fasting glucose 79 mg/dL, fasting insulin 8 uIU/mL.

Glycemic variability as the key metric for glycaemic control success: my coefficient of variation (CV) on CGM dropped from 41% to 22%. Target is <36%, with <30% being ideal.

Why this matters more than average glucose: large glucose swings cause oxidative stress, endothelial damage, and promote advanced glycation end-products (AGEs). A flat glucose line at 95 mg/dL is metabolically healthier than oscillating between 60 and 160, even if the average is the same.

5 0GraceAZ_72, carl_compliance, DanielChem_CHI and 2 others
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anna.melb_AU
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Sep 24, 2024 at 11:47 AM#4
marco_milano said:
A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

Can confirm. Same sequence, different timescale.

4 24tammy_FL, Dr.LipidDallas, alex_tucson and 1 other
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Dr.ObesityLA
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Sep 24, 2024 at 12:44 PM#5

Adding the clinical framing, because it changes how the question reads.

Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone:

TestBaselineMonth 3Month 6Month 12
Glucose (fasting)1121069284
Insulin (fasting)181487
HOMA-IR4.53.32.01.1
Uric Acid8.06.25.94.8

The insulin resistance improvement (HOMA-IR) is what my endo focuses on most. Going from 4.5 to near 1.0 is a metabolic transformation.

3 23jason_sac26, chris_chi24, tampaLisa73
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