A narrower follow-up, since the general answer is now clear:
Did your prescriber agree with that reading, and if not what was their objection?
COA_Karl said:The mechanism is more central than most summaries suggest.
I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.
COA_Karl said:The mechanism is more central than most summaries suggest.
Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were relying on physical fullness feel the effect fade while the appetite effect is still working.
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Browse GL BiochemCOA_Karl said:The mechanism is more central than most summaries suggest.
That reframing is the part I needed. Printing the relevant bit and taking it with me.
Adding the clinical framing, because it changes how the question reads. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.
Worth separating that from the pharmacology, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.